All you need to do is pick an NFL team that will win that week. Point spreads don't matter, although there is strategy because you can only use a team once. This year:
A spate of home losses by heavy favorites through Week 2 has resulted in the elimination of all but 27.2% (or 3,877 entries) of the original 14,266-entry field.
$1,000 to enter.
Related, check out Mina Kimes's podcast previewing the week 2 games. They get almost every game wrong, and again, they're not even worrying about point spreads.